Section 4 (Clinical Pharmacy Services), items 4.1, 4.3, 4.8
Section 5 (Patient Safety and Quality Assuaranse), item 5.1, 5.2, 5.6.
Click here [1] to download the ACPE description form
Nieko Punt [2] Kees Neef [3] Azucena Aldaz Pastor [4] Daniel J. Touw [5].
Christoph Hiemke [6] Branislava Miljković [10] Eric van Maarseveen [8] Antonio Gouveia [9]
Therapeutic drug monitoring (TDM) involves the measurement and interpretation of drug concentrations in order to individualise therapy. The indications for TDM include efficacy, compliance, monitoring drug-drug interactions, toxicity avoidance, guiding withdrawal of therapy, and drug should satisfy certain criteria to be suitable for TDM (narrow target range, significant pharmacokinetic variability, a reasonable relationship between plasma concentrations and clinical effects, established target concentration range, availability of cost-effective drug assay). By combining knowledge of pharmaceutics, pharmacokinetics, and pharmacodynamics, TDM enables the optimisation of drug therapy. Attention must be paid to the timing of blood sampling, the type of biological matrix, the measurement techniques, and the interpretation of results. To accurately interpret measured concentrations, it is important the request form contains all relevant information: time sample collected, time dose given, dosage regimen (dose, duration, dosage form), patient demographics (age/gender), other medications, relevant co-morbidities (e.g. renal/liver disease), indications for testing (e.g. toxicity, non-compliance). Drug concentrations should be interpreted in the context of the clinical data and hospital pharmacists need to be aware of many factors that influence measured concentrations. Performing TDM requires a multidisciplinary approach and collaboration by a TDM team, comprised of clinicians, nurses, hospital/clinical pharmacists.
Participants will be able to:
Topics of EAHP events are fixed both in a top-down manner by the Scientific Committee and directly arising from the fields the members daily are moving in, such as:
and in a bottom-up manner by
Generally, topics will be approved by the EAHP Board. Educational need and gaps between best and current practice and actual versus desired skills respectively can be easily screened by the Scientific Committee from
The aim of this Academy Seminar is to provide tools which improve the position of the hospital pharmacist in Research & Development activities adapted to the own institution’s environment.
Clinical pharmacokinetics, pharmacokinetic parameters, pharmacokinetic variability, saturable pharmacokinetics, therapeutic range, analytical methods, dry blood spot, pharmacogenomics, PK-PD modelling, population pharmacokinetics, therapeutic drug monitoring, medicines optimisation, phenotyping, modeling, antibiotics, antifungals, dose optimisation, individual patient, antiepileptics, antipsychotics, TDM service, software, InsightRX, DoseMeRx, MwPharm++, beta lactam antibiotics, aminoglycosides, fluoroquinolones, azole antifungal drugs, clinical case, pharmacogenetic test, neuropsychiatric drugs, clinical case, dose adjustment, immunosuppressive and oncolytic agents, comedication, drug-drug interaction, patient’s characteristics, voriconazole, tacrolimus, business case, bussulfan, collaboration and TDM service.
Links
[1] https://www.eahp.eu/sites/default/files/tdm.pdf
[2] http://www.eahp.eu/content/nieko-punt
[3] http://www.eahp.eu/content/prof-dr-kees-neef
[4] http://www.eahp.eu/content/prof-dr-azucena-aldaz-pastor
[5] http://www.eahp.eu/content/prof-dr-daniel-j-touw
[6] http://www.eahp.eu/content/prof-dr-christoph-hiemke
[7] http://www.eahp.eu/content/prof-branislava-miljković
[8] http://www.eahp.eu/content/dr-erik-van-maarseveen
[9] http://www.eahp.eu/content/antonio-gouveia
[10] http://www.eahp.eu/content/prof-branislava-miljkovi%C4%87
[11] https://learning.bmj.com/learning/course-intro/.html?courseId=10064435&locale=en_GB